18F-FDG PET/CT to evaluate the therapeutic effect of liposomal albendazole on hepatic alveolar echinococcosis
10.3760/cma.j.issn.2095-2848.2018.02.006
- VernacularTitle:18F-FDG PET/CT显像评价肝泡型包虫病阿苯达唑脂质体治疗的疗效
- Author:
Xiaohong LI
1
;
Qizhou ZHANG
;
Yongde QIN
;
Yubin LI
;
Bin XIE
;
Yibulayin · AMINA
Author Information
1. 新疆医科大学第一附属医院核医学科
- Keywords:
Echinococcosis,hepatic;
Albendazole;
Positron-emission tomography;
Tomography,X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(2):101-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of radioactivity of the marginal zone of hepatic alveolar echinococcosis (HAE) before and after the treatment with albendazole liposomes,and to explore the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging in therapeutic response.Methods From July 2011 to July 2015,37 patients (21 males,16 females;average age (53±12) years) with HAE were selected and underwent 18F-FDG PET/CT imaging before routine medication with albendazole liposomes (10 mg · d-1 · kg-1),and the maximum standardized uptake value (SUVmax) of the margin of lesions was calculated.PET/CT imaging was performed again 6 months later to measure the SUVmax of the marginal lesions.Two-sample t test was used to analyze the data.Results In 37 patients with HAE,SUVmax before treatment was 4.88± 1.86,which was higher than that of 24 patients with reduced lesion size after treatment (3.63± 1.38;t =5.24,P＜ 0.001).Conclusion 18F-FDG PET/CT is useful for evaluating the radioactivity of marginal zone of HAE before and after the treatment with albendazole liposomes,and SUVmax of the marginal zone could be valuable for therapeutic response evaluation.
