Clinical value of 125I seeds implantation in treatment of lymph nodes metastases from 131I refractory differentiated thyroid carcinoma
10.3760/cma.j.issn.2095-2848.2018.01.003
- VernacularTitle:125I粒子植入治疗131I难治性分化型甲状腺癌淋巴结转移的临床价值
- Author:
Wenwen ZHANG
1
,
2
;
Shanhu HAO
;
Zhiguo WANG
;
Tong ZHANG
;
Liqiu JI
;
Xiangyan GE
;
Guoxu ZHANG
Author Information
1. 110016 锦州医科大学中国人民解放军沈阳军区总医院研究生培养基地
2. 110016 沈阳军区总医院核医学科
- Keywords:
Thyroid neoplasms;
Neoplasm metastasis;
Lymph nodes;
Brachytherapy;
Iodine radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2018;38(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of 125I seeds implantation (RSI) for treatment of lymph nodes metastases (LNM) in patients with 131I refractory differentiated thyroid carcinoma (RAIR-DTC).Methods A total of 42 RAIR-DTC patients with LNM (14 males,28 females,median age 49 years) who underwent RSI guided by CT from January 2015 to June 2016 were retrospectively analyzed.All patients underwent CT and their serum thyroglobulin (Tg) levels were measured 2,4 and 6 months post-treatment.The LNM size and serum Tg levels before and after treatment were compared,and the curative effect of RSI for complications was observed.Paired t test,x2 test,repeated measurement analysis of variance,Spearman correlation analysis were used to analyze the data.Results Two patients (4.76％) achieved complete remission,9(21.43％) achieved partial remission,29(69.05％) had no change,2(4.76％) were with progressive disease in all 42 patients.Thetotal effective rate was 95.24％ (40/42).The LNM diameter post-treatment was (1.39±0.75) cm,significantly lower than that before treatment ((1.99±0.38) cm;t=5.557,P＜0.01).The Tg level 2,4 and 6 months posttreatment was (53.24± 14.05),(33.17±7.61) and (25.93± 10.91) μg/L,respectively,which was significantly lower than that before treatment ((57.72± 15.23) μg/L;F =23.612,all P＜0.05).The age,sex,metastatic site,and the number of seeds implanted in each lesion were not the influencing factors on RSI (x2 values:0.569-15.884,rs =0.277,all P＞0.05).The LNM size was the influencing factor on RSI (x2=4.524,P＜0.05).Conclusions 125I RSI can significantly alleviate the clinical symptoms of RAIR-DTC patients with LNM,and the LNM size has relevance for the treatment effect.The clinical follow-up time of serum Tg level can be extended to 6 months or even longer.
