Influence of discontinuance of methimazole and propylthiouracil on 24 h radioactive iodine uptake in normal rats
10.3760/cma.j.issn.2095-2848.2017.03.009
- VernacularTitle:甲巯咪唑和丙硫氧嘧啶停药时间对正常大鼠甲状腺24h摄131I率的影响
- Author:
Rong NIU
1
;
Jianfeng WANG
;
Jianhua JIN
;
Yuetao WANG
Author Information
1. 213003,常州市第一人民医院核医学科
- Keywords:
Thyroid gland;
Iodine uptake;
Iodine radioisotopes;
Methimazole;
Propylthiouracil;
Rats
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(3):162-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of discontinuance of methimazole (MMI) and propylthiouracil (PTU) on 24 h radioactive iodine uptake(RAIU) in normal rats.Methods A total of 66 female SD rats were randomly divided into 3 groups by simple random sampling method.MMI group (30 rats) received MMI with a dose of 0.6 mg · ml-1 · d-1 orally for 2 weeks,PTU group (30 rats) received PTU with a dose of 6 mg · ml-1 · d-1 orally for 2 weeks.At 1,3,5,7 and 9 d after MMI or PTU was discontinued,6 rats were sacrificed to measure 24 h RAIU respectively.The control group (6 rats) received normal saline with a dose of 1 ml/d orally for 2 weeks,and then they were sacrificed to measure 24 h RAIU too.Data were analyzed with two-sample t test or t'test.Results Thyroid 24 h RAIU in normal rats was (14.6±4.3) %.The 24 h RAIU on 1,3,5,7 and 9 d was (4.6±0.7) %,(24.2±7.2) %,(13.1 ±2.9) %,(14.1±2.6) %,(16.1 ±3.7)% respectively after MMI withdrawal.The 24 h RAIU was significantly lower than that in control group at day 1 (t'=5.55,P<0.01),higher at day 3 (t=-2.83,P<0.05),and returned to the normal level at day 5,7,9 (t =0.68,0.24,-0.67,all P>0.05).The 24 h RAIU on 1,3,5,7 and 9 d was (1.9±0.8)%,(3.3±1.2)%,(7.7±2.4)%,(29.0±4.0)%,(17.1±4.8)% respectively after PTU withdrawal.It was lower than that in control group (t=7.01,6.10,3.40,all P<0.05) at day 1,3,5,and higher at day 7 (t=-5.97,P<0.01).The 24 h RAIU of 9 d showed no difference when compared with that in control group (t=-0.95,P>0.05).Conclusions MMI and PTU can inhibit the iodine uptake of thyroid,the 24 h RAIU returns to normal level at day 5 after withdrawal of MMI and at day 9 after withdrawal of PTU in euthyroid rats.