Human Adenovirus Type 5 as a Delivery Vector is Not Neutralized in Field Serum Samples of Cattle, Pig, and Goat of Republic of Korea.
10.4167/jbv.2014.44.3.269
- Author:
Su Mi KIM
1
;
Hyang Sim LEE
;
Kwang Nyeong LEE
;
Jong Hyeon PARK
;
Young Joon KO
;
Byounghan KIM
Author Information
1. Foot-and-Mouth Disease Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affairs, Gyeonggi-do, Korea. beliefsk@korea.kr
- Publication Type:Brief Communication
- Keywords:
Human adenovirus type 5;
Antibody;
Serum;
Korea
- MeSH:
Adenoviruses, Human*;
Animals;
Antibodies, Neutralizing;
Cattle*;
Gene Expression;
Goats*;
Korea;
Livestock;
Republic of Korea*;
Vaccines
- From:Journal of Bacteriology and Virology
2014;44(3):269-273
- CountryRepublic of Korea
- Language:English
-
Abstract:
Human adenovirus type 5 (hAd5) vectors have been demonstrated to be useful vehicles for gene expressions in animals. However, it has not been reported whether hAd5 transduction might be hampered in the sera of livestock animals in Republic of Korea. We collected 205 samples of livestock animals, such as pig (n=84), cattle (n=84), and goat (n=37) in Korea. The neutralizing antibody (NAb) titers to hAd5 virus were less than 15 in most of samples. Only 8% of goat samples had a NAb titer of 15 or 30. Thus, we showed that hAd5 virus was not neutralized in sera from cattle, pig, and goat, and suggest that the hAd5 vector could be used for the effective delivery of vaccines or proteins in livestock animals in the field.
