Advances in the role of microRNAs in liver cancer stem cells
10.3760/cma.j.issn.1007-8118.2018.09.018
- VernacularTitle:MicroRNA在肝癌干细胞中的作用研究进展
- Author:
Lianjie NIU
1
;
Yamin ZHANG
Author Information
1. 300070,天津医科大学一中心临床学院
- Keywords:
Liver cancer,stem cell;
MicroRNA;
Cell marker
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(9):641-644
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer stem cells have the abilities of infinite proliferation,self-renewal,chemoradiation tolerance,high tumorigenicity and stem cell characteristics.The proportion of liver cancer stem cells is positively correlated with the malignancy of the tumor.MicroRNAs (miRNA) can regulate the expression of many genes by degrading mRNA or inhibiting mRNA translation.MicroRNAs also play an important role in a series of life activities such as embryogenesis,tissue and organ development,cell growth and differentiation,apoptosis,disease development.In-depth study of specific miRNA in the occurrence and development of liver cancer and its role in LCSCs,it may provide a new target for prevention and treatment of recurrence and metastasis of liver cancer.
