The expressions and clinical significance of Ezrin and PTEN protein in intrahepatic cholangiocarcinoma
10.3760/cma.j.issn.1007-8118.2018.08.010
- VernacularTitle:肝内胆管细胞癌中Ezrin和PTEN蛋白的表达及其临床意义
- Author:
Wei DONG
1
;
Lu LIU
;
Ying CHEN
;
Yan ZHENG
;
Yong LI
;
Qingsong KANG
;
Feibo LI
Author Information
1. 舟山市普陀区人民医院普外科
- Keywords:
Intrahepatic cholangiocarcinoma;
Ezrin protein;
Phosphatase and tensin homolog deleted from chromosome (PTEN);
Immunohistochemistry
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(8):537-541
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions and the clinicopathologic significance of Ezrin and PTEN protein in intrahepatic cholangiocarcinoma.Methods The ICC tissues (the ICC group) and the corresponding para-carcinoma tissues (the control group) were collected from 50 patients with intrahepatic cholangiocarcinoma (IHC) to detect the expressions of Ezrin and PTEN protein by using SP immunohistochemistry (IHC).The clinicopathologic parameters were analyzed.Results The positive expression rates of Ezrin were 78.0％ (39/50) and 46.0％ (23/50) in the ICC group and the control group,respectively.The difference in expression between the two groups was statistically significance (P＜0.05).The expression of Ezrin in the ICC group was highly related to tumor size,differentiation grade,TNM stage,and lymphatic metastasis (P＜0.05),but it was not related to age,gender,serum CA19-9 level,hepatitis B virus infection,intrahepatic duct calculus (P＞0.05).The positive expression rates of PTEN was 46.0％ (23/50) and 88.0％ (44/50) in the ICC group and the control group,respectively.The difference in expression between the two groups was statistically significance (P＜0.05).The expression of PTEN in the ICC group was highly related to differentiation grade,TNM stage,and lymphatic metastasis (P＜0.05),but it was not related to age,gender,serum CA19-9 level,hepatitis B virus infection,tumor size,intrahepatic duct calculus (P＞0.05).There was a negative correlation between the expression of Ezrin and PTEN protein in ICC (r=-0.382,P＜0.01).Conclusion The abnormal and negative correlation between the expression of Ezrin and PTEN protein in ICC may play an important role in invasion and metastasis of ICC.
