Research advances on clinical applications of cell-free DNA from peripheral blood in liver cancer
10.3760/cma.j.issn.1007-8118.2018.05.017
- VernacularTitle:血液游离DNA检测肝癌的临床应用研究进展
- Author:
Yang WANG
1
;
Zhenyuan BIAN
;
Chun YIN
;
Feng ZHOU
;
Kaishan TAO
;
Jinliang XING
Author Information
1. 第四军医大学西京医院肝胆外科
- Keywords:
Liver cancer;
Cell-free DNA;
Screening;
Diagnosis
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(5):348-351
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is a malignant tumor with the characteristics of high morbidity and mortality.However,the routine detection methods for the liver cancer such as imaging tests and pathological detection are with low specificity and sensitivity.And it's also hard to detect the condition of patients dynamically.Cell-free DNA (cfDNA) is the DNA fragment that is away from the extracellular and exists in the blood,which contains genetic information from the organism.The related disease information could be reflected on the cfDNA in patients with liver cancer,indicating that cfDNA has great potential in the screening,diagnosis,treatment and prognosis of liver cancer.The clinical applications of cfDNA can make up for the deficiency of existing detection methods and achieve noninvasive and dynamic monitoring of liver cancer.This article will present a review on the progress of clinical applications of cfDNA in liver cancer.
