Postoperative prophylactic anticoagulation in the prevention of portal venous thrombosis in patients after laparoscopic splenectomy: a Meta-analysis
10.3760/cma.j.issn.1007-8118.2018.05.012
- VernacularTitle:腹腔镜脾切除术后抗凝治疗预防门静脉系统血栓的Meta分析
- Author:
Yabin YU
1
;
Yan SONG
;
Ya CHEN
;
Fuzhen QI
Author Information
1. 南京医科大学附属淮安第一医院肝胆外科
- Keywords:
Portal vein system thrombosis;
Anticoagulants;
Laparoscopic splenectomy;
Meta-analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(5):333-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effectiveness and safety of prophylactic anticoagulation in the prevention of portal venous thrombosis (PVST) in patients after laparoscopic splenectomy.Methods A systematic search of the PubMed,Embase,Cochrane Library,Sinomed,Wangfang,Weipu and CNKI databases was performed to identify studies which compared outcomes in patients with or without prophylactic anticoagulation after laparoscopic splenectomy.The quality of the included studies was assessed using the Cochrane collaboration tool and the Newcastle-Ottawa Scale.Heterogeneity was evaluated using the x2 and I2 tests.The primary outcome was the incidence of postoperative PVST.Results Five studies were included into this review,which involved 206 and 168 patients with or without prophylactic anticoagulation,respectively.The incidence of PVST was significantly reduced with prophylactic anticoagulation with an odds ratio (OR) of 0.32 [95％ confidence interval (CI),0.13 ～0.79,P＜0.05].Conclusion Prophylactic anticoagulation resulted in a significant reduced incidence of PVST after laparoscopic splenectomy.
