Prognosis of post-transplant diabetes mellitus in recipients with steatotic donor livers
10.3760/cma.j.issn.1007-8118.2018.05.001
- VernacularTitle:脂肪变性供肝肝移植术后新发糖尿病的预后分析
- Author:
Nan ZHANG
1
;
Wenli YU
;
Mingwei SHENG
;
Yijie DING
;
Man WU
;
Xinyue ZHANG
;
Hongyin DU
Author Information
1. 天津医科大学—中心临床学院
- Keywords:
Liver transplantation;
Donor liver steatosis;
Post-transplant diabetes mellitus;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(5):289-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors and prognosis of post-transplant diabetes mellitus (PTDM) in recipients with steatotic donor livers.Method The clinical data of 182 patients who underwent liver transplantation from donors with liver steatosis in Tianjin First Central Hospital from June 2002 to December 2010 were retrospectively analyzed.There were sixteen patients with PTDM and one hundred sixtysix without PTDM.The clinical data of these patients were compared and the risk factors were evaluated by COX regression analysis.The 1-,3-,5-year cumulative survival rates were analyzed after liver transplantation.Result The variables which included sex,pretransplant serum creatinine level,model for end-stage liver disease (MELD) score,intraoperative red blood cell transfusion,and post-transplant biliary complications were significantly different between the two groups.Multivariate Cox regression analysis showed that living-donor,pretransplant fasting blood glucose and post-transplant biliary complications could affect the survival time of patients in PTDM group.The 1-,3-and 5-year cumulative survival rates in the PTDM group were 81.3％,68.8％ and 62.5％,which were significantly lower than those in the non-PTDM group (95.2％,86.1％ and 80.7％ respectively,P ＜ 0.05).Conclusions Living-donation,pretransplant fasting blood glucose and post-transplant biliary complications had a worse prognosis in the PTDM group.A comparatively better long-term survival after liver transplantation can be achieved by reducing the risk factors and the occurrence of PTDM.
