A retrospective study on patients with BCLC intermediate stage HCC treated with TACE and hepatic resection
10.3760/cma.j.issn.1007-8118.2018.04.006
- VernacularTitle:肝动脉化疗栓塞联合肝切除术治疗巴塞罗那中期肝癌的回顾性分析
- Author:
Lisha LAI
1
;
Xianhui LIAN
;
Mingan LI
;
Chun WU
;
Jiesheng QIAN
;
Shouhai GUAN
;
Zaibo JIANG
;
Mingsheng HUANG
;
Junwei CHEN
Author Information
1. 广州市第一人民医院华南理工大学附属第二医院放射科
- Keywords:
Hepatocellular carcinoma;
Transcatheter arterial chemoembolization;
Hepatectomy;
Progression-Free survival;
Overall survival
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(4):235-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the treatment outcomes using transcatheter arterial chemoemboliza tion (TACE) followed by hepatic resection (HR) in patients with BCLC stage B hepatocellular carcinoma (HCC).Methods The clinical data of 46 patients with intermediate stage HCC in the Third Affiliated Hospital of Sun Yat-sen University from Jan.2004 to Jul.2013 were analyzed retrospectively.The baseline characteristics of these 46 patients were recorded.The levels of serum aspartate transaminase (AST),ala nine aminotransferase (ALT),total bilirubin (TBil),and albumin (Alb),and the prothrombin time (PT) at 1 week and 1 month after HR were compared with those at the baseline.The overall survival (OS) and progression-free survival (PFS) were analyzed by the Kaplan-Meier method.The effect on PFS by the changes in the alpha-fetal protein level and the modified Response Evaluation Criteria In Solid Tumors (mRECIST) after TACE were analyzed using the log-rank test.Results The number of cycles of TACE given before HR was 1.7 ± 1.1.The mean time interval between TACE and HR was 3.0 ± 3.2 months.The levels of serum AST,ALT,TBil,Alb and PT at 1 week after HR were significantly different from the baseline levels (P ＜ 0.05),while those levels at 1 months after HR showed no significant difference from the baseline levels (P＞0.05).The mean OS was 72.1 ±6.0 (95％ CI 60.36 ～83.86) months.The median PFS was 46.0 (95％ CI:42.60～49.40) months.Using the log-rank test,the decrease in AFP (P ＜ 0.001) and the improvement in mRECIST (CR + PR) (P ＜ 0.001) after TACE were significantly associated with better PFS.Conclusions HR after TACE was safe for patients with BCLC stage B HCC and might prolong the PFS and OS.Decreases in AFP level and improvement in mRECIST (CR + PR) after TACE were factors they could be used to predict the survival outcomes of HR.
