Prognostic factors for patients with pancreatic head carcinoma undergoing operation: a retrospective study on Surveillance, Epidemiology, and End Results using population-based data
10.3760/cma.j.issn.1007-8118.2018.02.009
- VernacularTitle:胰头癌手术患者的预后因素:基于SEER数据库的回顾性研究
- Author:
Hangbao LI
1
;
Jun ZHOU
;
Xiaojun WU
;
Jie MIN
;
Fengqing ZHAO
;
Wen LIU
;
Liang LI
;
Feijie YU
;
Shuai CHEN
Author Information
1. 嘉兴市第一医院肝胆胰外科
- Keywords:
Pancreatic head carcinoma;
Prognosis;
TNM classification;
Survival rate
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(2):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the survival of patients with pancreatic head carcinoma undergoing surgery,and to evaluate the clinicopathological factors associated with prognosis.Methods The data of 4 814 patients who underwent surgery for pancreatic head carcinoma from 2004 to 2009 were extracted from the US SEER database.The life table was used to calculate the survival rate at 5-years.The Kaplan-meier method was used to construct the survival curves of the patients.The univariate and Cox multivariate regression analysis were applied to evaluate the prognostic factors.and the univariate analysis was evaluated by the log-rank x2 test.Results The overall 5-year survival of 4 818 pancreatic head carcinoma patients was 16.3％.The median survival was 18.9 months,and the 5-year survival rates of the stage Ⅰ A,Ⅰ B,Ⅱ A,Ⅱ B,Ⅲ and Ⅳ patients were 38.8％,35.3％,21.8％,12.2％,9.1％,and 7.3％,respectively.The difference was statistically significant (x2 =287.702;P ＜ 0.05).The factors including sex,age,years of diagnosis,pathological grading,tumor size,extent of invasion,lymph node metastasis,distant metastasis,and pathological pattern (all P ＜ 0.05) influenced the survival rate on univariate analysis.There was no clear correlation between race,number of lymph node examined and prognosis.The factors including sex,age,years of diagnosis,pathological grading,tumor size (AJCC 8th),range,extent of invasion,lymph node metastasis,distant metastasis,and pathological pattern (all P ＜ 0.05) were independent prognostic factors on multivariate analysis.Conclusions With the increase of TNM staging,the overall survival of patients with pancreatic head carcinoma undergoing surgery gradually decreased.Factors including sex,age,years of diagnosis,pathological grading,tumor size,extent of invasion,lymph node metastasis,distant metastasis,and pathological pattern were independent prognostic factors of overall survival.
