Roles of exosomes in the diagnosis and treatment of patients with pancreatic cancer
10.3760/cma.j.issn.1007-8118.2018.01.017
- VernacularTitle:外泌体在胰腺癌患者诊疗中的作用
- Author:
Yixuan DING
1
;
Fei LI
Author Information
1. 100053,首都医科大学宣武医院普通外科
- Keywords:
Exosomes;
Pancreatic cancer;
Glypican-1 (GPC-1);
Diagnosis;
Treatment
- From:
Chinese Journal of Hepatobiliary Surgery
2018;24(1):64-67
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are small membrane bound vesicles typically 30 ～ 150 nm in size which are widely distributed in the body fluids.The cytosol is rich in proteins and nucleic acids which mediates communication between different cells and transporting substances.Exosomes are involved in pancreatic cancer initiation and progression by promoting the formation of tumor microenvironment,enhancing gemcitabine resistance.GPC1 + circulating exosomes and high exosome levels of microRNA-10b serve as potertial non-invasive diagnostic tools to detect pancreatic cancer in the early stage.Meanwhile,exosomes could successfully deliver genetic drugs,anticancer drugs to target cells.In this article,we provide a review on the recent advances on exosomes in the diagnosis and treatment of pancreatic cancer.
