The expression and clinical significance of the long non-coding RNA-BC043614 in pancreatic ductal adenocarcinoma
10.3760/cma.j.issn.1007-8118.2017.12.011
- VernacularTitle:长链非编码RNA-BC043614在胰腺导管腺癌中的表达及其临床意义
- Author:
Yongping ZHOU
1
;
Bo CHEN
;
Tu DAI
;
Wenzhou DING
;
Xiaohua JIANG
;
Ming XU
;
Xujing WANG
;
Yongkun WANG
;
Haixin QIAN
Author Information
1. 苏州大学附属第一医院肝胆外科
- Keywords:
Long noncoding RNA;
Pancreatic ductal adenocarcinoma;
Realtime fluorescence quantitative PCR(qRT-PCR);
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(12):832-835
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of the long non-coding RNA-BC043614 in pancreatic ductal adenocarcinoma (PDAC) and to analyse the relationship between the clinical pathological data and the prognosis of PDAC.Methods The clinical data of 42 patients who had PDAC treated from June 2013 to June 2014 were retrospectively analyzed.Real-time fluorescence quantitative PCR (qRT-PCR) was performed to detect the difference in expression of lncRNA-BC043614 between PDAC and its adjacent normal tissues.Correlation between the expression of lncRNA-BC043614 in PDAC and the clinical pathological characteristics was analyzed by the x2 test.The potential of lncRNA-BC043614 in predicting prognosis in patient with PDAC after operation was assessed using the Log-rank test and the Cox's proportional hazards regression model.Results The expression of lncRNA-BC043614 was markedly higher in PDAC than in its adjacent normal tissues (P ＜0.05).The expression of lncRNA-BC043614 in PDAC was significantly correlated with tumor size,tumor differentiation,vascular carcinoma,and CA19-9 serum levels (P ＜ 0.05).Patients with a higher expression of lncRNA-BC043614 in PDAC had a significantly shorter tumor-free survival (P ＜0.05).A high expression of lncRNA-BC043614 in PDAC was an independent risk factor of tumor-free survival in patients with PDAC after operation (P ＜ 0.05).Conclusions lncRNA-BC043614 was highly expressed in pancreatic cancer tissue and it correlated with the patient's tumor-free survival.lncRNA-BC043614 can be used as a new prognostic biomarker.
