Analysis of clinical efficacy, failure pattern and prognostic factors of comprehensive treatment for malignant mucosal melanoma of head and neck
10.3760/cma.j.issn.1004-4221.2018.12.002
- VernacularTitle:头颈部黏膜恶性黑色素瘤手术联合放疗的预后分析
- Author:
Shiran SUN
1
;
Junlin YI
;
Li GAO
;
Xiaodong HUANG
;
Jingwei LUO
;
Ye ZHANG
;
Shiping ZHANG
;
Kai WANG
;
Yuan QU
;
Runye WU
;
Qingfeng LIU
;
Xuesong CHEN
;
Jianping XIAO
;
Guozhen XU
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科
- Keywords:
Head neck neoplasmsm/radiotherapy;
Melanoma/radiotherapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2018;27(12):1041-1045
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy,failure pattern and prognostic factors of the malignant mucosal melanoma of the head and neck ( MMHN) in a single center. Methods The treatment pattern,clinical efficacy, failure pattern and prognostic factors of 194 M0MMHN patients admitted to our institution from 1982 to 2017 were retrospectively analyzed.Results The 5-year overall survival (OS),local recurrence-free survival ( LRFS ), regional recurrence-free survival ( RRFS ) and distant metastasis-free survival (DMFS) were 41. 4%,57. 8%,76. 5% and 46. 5%,respectively. The failure rate was calculated as 74. 6%(141/189).Among them,40% (56/141) had distant metastasis as the first pattern of treatment failure,37%(52/141) had local relapse,15%(21/141) had regional relapse,5%(7/141) had concurrent distant metastasis and local/regional relapse and 3% ( 5/141) had concurrent local and regional relapse. Multivariate analysis demonstrated that surgical margins (P=0. 001) and adjuvant radiotherapy (P=0. 000) were the independent prognostic factors for LRFS. Conclusions Surgery combined with radiotherapy can yield relatively high LRFS in the comprehensive treatment of MMHN.Distant metastasis is the major failure pattern.
