Research progress on prophylactic cranial irradiation in patients with surgically resected small cell lung cancer
10.3760/cma.j.issn.1004-4221.2018.11.018
- VernacularTitle:术后小细胞肺癌患者预防性脑照射研究进展
- Author:
Mengyuan CHEN
1
;
Xiao HU
;
Jin WANG
;
Ming CHEN
Author Information
1. 浙江中医药大学
- Keywords:
Lung neoplasm/postoperative prophylactic cranial irradiation;
Prognosis;
Reasearch progress
- From:
Chinese Journal of Radiation Oncology
2018;27(11):1026-1029
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of small cell lung cancer ( SCLC) is relatively low, which approximately accounts for 13％-20％ of all types of lung cancers. SCLC is characterized by high-degree malignancy and high metastasis and recurrence rates within a short period of time. Upon the confirmed diagnosis, limited-stage SCLC approximately accounted for 30％ of SCLC and merely 5％ of these patients were eligible for surgery. Over half of the patients who obtained complete remission after chemoradiotherapy presented with brain metastases. The postoperative incidence of brain metastases in patients with stageⅠ,ⅡandⅢSCLC was 6％-14％,13％-38％ and 11％-36％, respectively. Prophylactic cranial irradiation ( PCI) can enhance the overall survival rate of patients with complete remission after chemoradiotherapy and reduce the incidence of brain metastasis, which is a pivotal part of comprehensive treatment of limited-stage SCLC. However, the application of PCI remains controversial in clinical practice and the clinical efficacy for patients with surgically resected SCLC significantly varies. In this article, literature review was conducted and the research progress in this field was summarized.
