Prognostic analysis of definitive three-dimensional radiotherapy for non-surgically resectable esophageal squamous cell carcinoma:a multi-center retrospective study ( 3JECROG R-01)
- VernacularTitle:多中心食管鳞癌根治性三维放疗的预后分析——3JECROG R-01
- Author:
Xin WANG
1
;
Lan WANG
;
Junqiang CHEN
;
Wencheng ZHANG
;
Xiaomin WANG
;
Xiaolin GE
;
Wenbin SHEN
;
Miaomiao HU
;
Qianqian YUAN
;
Yonggang XU
;
Chongli HAO
;
Zhiguo ZHOU
;
Shuai QIE
;
Na LU
;
Qingsong PANG
;
Yidian ZHAO
;
Xinchen SUN
;
Kaixian ZHANG
;
Gaofeng LI
;
Ling LI
;
Xueying QIAO
;
Miaoling LIU
;
Yadi WANG
;
Lei DENG
;
Wenqing WANG
;
Nan BI
;
Tao ZHANG
;
Wei DENG
;
Chen LI
;
Wenjie NI
;
Xiao CHANG
;
Weiming HAN
;
Zongmei ZHOU
;
Jun LIANG
;
Qinfu FENG
;
Lvhua WANG
;
Dongfu CHEN
;
Jima LY
;
Shuchai ZHU
;
Chun HAN
;
Zefen XIAO
Author Information
- Keywords: Esophageal neoplasm/radiotherapy; Esophageal neoplasm/chemotherapy; Prognosis
- From: Chinese Journal of Radiation Oncology 2018;27(11):959-964
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the survival and prognostic factors of esophageal cancer treated with definitive ( chemo ) radiotherapy by applying novel radiation techniques including three-dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiotherapy (IMRT). Methods Clinical data of 2762 patients with non-operated esophageal squamous cell carcinoma who underwent definitive ( chemo ) radiotherapy from 2002 to 2016 in 10 hospitals were retrospectively analyzed.The prognostic factors were also identified and analyzed. Results The median follow-up time was 60. 8 months. The 1-, 2-, 3-and 5-year overall survival (OS) of all patients was 71. 4％,48. 9％,39. 3％,and 30. 9％,respectively.The 1-,2-,3-and 5-year progression-free survival (PFS) was 59.5％,41.5％,35.2％,and 30％,respectively.The median survival was 23 months.The median time to progression was 17. 2 months.Multivariate analysis demonstrated that age, primary tumor location, clinical stage, tumor target volume, EQD2 and treatment mode were the independent prognostic factors for OS.Primary tumor location,clinical stage,tumor target volume and EQD2 were the independent prognostic factors for PFS. Conclusions In this first large-scale multi-center retrospective analysis of definitive ( chemo) radiotherapy for esophageal squamous cell carcinoma in China, the 5-year OS of patients with esophageal squamous cell carcinoma is significantly improved by 3DCRT, IMRT combined with chemotherapy drugs. However, the findings remain to be validated by prospective clinical trials with high-level medical evidence.
