Preliminary analysis of clinical efficacy of whole brain simultaneous integrated boost intensity-modulated radiotherapy in patients with brain metastases
10.3760/cma.j.issn.1004-4221.2018.11.001
- VernacularTitle:脑转移癌全脑同期推量IMRT疗效初步分析
- Author:
Na CHANG
1
;
Liting QIAN
;
Yufei ZHAO
;
Ning GE
;
Qing ZHOU
;
Youyi XU
;
Jinmei FANG
;
Liu YANG
Author Information
1. 安徽省肿瘤医院(中国科学技术大学附属第一医院西区)肿瘤放疗科
- Keywords:
Neoplasms metastasis,brain/whole brain simultaneous integrated boost intensity-modulated radiotherapy;
Neoplasms metastasis,brain/whole brain radiotherapy;
Treatment outcome
- From:
Chinese Journal of Radiation Oncology
2018;27(11):955-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminary investigate the clinical efficacy of whole brain simultaneous integrated boost intensity-modulated radiotherapy ( SIB-IMRT ) in patients diagnosed with brain metastases ( BM) . Methods Fifty-two cases of BM admitted to our hospital from January 2016 to December 2017 were equally recruited and randomly divided into the observation and control groups. Patients in the observation group were treated with SIB-IMRT, and those in the control group received conventional whole brain radiotherapy (WBRT).The clinical efficacy and prognosis were statistically compared between two groups. Results The ORR in the observation group was 77％, significantly higher than 27％ in the control group (P=0. 00).The median survival in the observation group was 384 d,significantly longer compared with 211 d in the control group (P=0. 00).All patients in both groups successfully completed corresponding treatment. Acute adverse reactions were mainly 1-2 grade reactions. Conclusions SIB-IMRT is an efficacious and safe treatment of BM,which yields tolerable adverse events and deserves application in clinical practice.
