Application mechanisms of radiotherapy combined with immune checkpoint inhibitors
10.3760/cma.j.issn.1004-4221.2018.10.001
- VernacularTitle:放疗联合免疫检查点抑制剂治疗肿瘤的应用基础
- Author:
Zhouguang HUI
1
;
Meng YUAN
;
Yu MEN
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院特需医疗部
- Keywords:
Neoplasms/radiotherapy;
Neoplasms/immunotherapy;
Immune checkpoint inhibitor;
Abscopal effect
- From:
Chinese Journal of Radiation Oncology
2018;27(10):875-879
- CountryChina
- Language:Chinese
-
Abstract:
Remarkable advances have been made in immunotherapy,especially immune checkpoint inhibitors.However,only less than 30％ patients would respond to single checkpoint inhibitors.Radiotherapy can augment the anti-tumor immune responses elicited by immunotherapy,either by way of synergy or complementation.This article reviews the mechanisms,the advances and challenges in combination therapy.
