Analysis of radiotherapy curative effect and prognostic factors in 164 patients with extracranial oligometastases
10.3760/cma.j.issn.1004-4221.2018.07.010
- VernacularTitle:164例颅外寡转移放疗疗效及预后分析
- Author:
Xianwen ZHANG
1
;
Huihui ZHANG
;
Hongbo XU
;
Yongchun ZHOU
;
Gengming WANG
;
Yan ZHOU
;
Feng CAI
;
Hao JIANG
Author Information
1. 233004,蚌埠医学院第一附属医院肿瘤放疗科
- Keywords:
Neoplasms oligometastases;
Extracranial oligometastases;
Neoplasms/radiotherapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2018;27(7):669-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of radiotherapy,as well as the prognostic factors of survival in patients with extracranial oligometastases. Methods A total of 164 patients who underwent intensity-modulated radiotherapy ( IMRT ) of the extracranial oligometastases, from January 2013 to December 2016, were enrolled in the study. The short-term efficacy, local control rate, overall survival, progression free survival and adverse effects of treatment were observed. Results Short-term efficacy was assessed within the first 1-3 months after the end of radiotherapy. The objective response rate (CR+PR) was 78. 7% and the short-term efficacy is mainly related to the T stage of primary tumor ( P＝0. 004).Until the last follow-up,all patients with 1-,2-and 3-year LC were 89. 8%,82. 5% and 74. 9% respectively.Univariate analysis showed that the influencing factors of LC include tumor size and gross tumor volume dose ( all P＜0. 05),multivariate analysis found no significant influence factors. The 1-,2- and 3-year OS were 83. 4%, 69. 6% and 54. 6% respectively. Univariate and multivariate analysis showed that the primary tumor sources, metastasis organs,whether synchronous or adjuvant chemotherapy and short-term efficacy were independent prognostic factors in patients of OS ( P＜0. 05 ).Main toxicity-associated events were grade 1-2 acute reactions,with only 6 patients experiencing grade 3 toxicity;no grade≥4 toxic reactions or treatment-related deaths occurred. Conclusions Radiation therapy for the treatment of extracranial oligometastases can achieve good curative effect,is well-tolerated and has low toxicity.
