Dosimetry and short term effect comparison of CT-guided interstitial brachytherapy and intracavitary brachytherapy for locally advanced cervical cancer
10.3760/cma.j.issn.1004-4221.2018.06.011
- VernacularTitle:局部晚期宫颈癌CT引导组织间插植BT与腔内BT剂量学与近期疗效比较
- Author:
Zhongshan LIU
1
;
Jie GUO
;
Yangzhi ZHAO
;
Xia LIN
;
Xiaojun REN
;
Hongyong WANG
;
Ling QIU
;
LiYunfeng
;
Tiejun WANG
Author Information
1. 吉林大学第二医院肿瘤放疗科
- Keywords:
Cervical neoplasms/brachytherapy;
Brachytherapy;
interstitial;
Brachytherapy;
intracavitary;
Dosimetry
- From:
Chinese Journal of Radiation Oncology
2018;27(6):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the dosimetric advantage of computed tomography-guided interstitial brachytherapy compared with the conventional intracavitary brachytherapy for locally advanced cervical cancer,offering a more advantageous clinical treatment approach. Methods Twenty-eight locally advanced cervical cancer patients with bulky tumors ( tumor size>5 cm) after external beam radiotherapy received computed tomography-guided interstitial brachytherapy. Dosimetric outcomes of the current study, including the total dose ( external beam radiotherapy+ brachytherapy ) D90 for the HR-CTV and D2cc for the bladder,rectum, and sigmoid, were compared with a former patient group consisting of 30 patients who received the conventional intracavitary brachytherapy ( uterine tandem+ ovoid pairs ) . Results The mean D90 value for HR-CTV in the intracavitary brachytherapy group and interstitial brachytherapy group were (76.9±5. 7) and ( 88.1± 3. 3) Gy, respectively. The D2cc for the bladder, rectum, and sigmoid in the intracavitary brachytherapy group and interstitial brachytherapy group were (84.7±6. 8) Gy,(69.2±4. 2) Gy,(67.8±4. 5) Gy and (81.8±6. 5) Gy,(6.8±4. 0) Gy,(64.8±4. 1) Gy,respectively.1-year local tumor control rate in the intracavitary brachytherapy group and interstitial brachytherapy group were 59. 3％ and 85. 2％, respectively. Conclusions CT-guided interstitial brachytherapy shows a significant dosimetric advantage compared with the conventional intracavitary brachytherapy, and is, thereby, clinically possible feasible. However,the long term curative effect and toxicity need to be further investigated.
