The Clinical significance of plasma Epstein-Barr virus DNA in nasopharyngeal carcinoma
10.3760/cma.j.issn.1004-4221.2018.06.001
- VernacularTitle:鼻咽癌患者血浆EBV-DNA检测的临床价值
- Author:
Huili WANG
1
;
Xiaodong HUANG
;
Yuan QU
;
Kai WANG
;
Runye WU
;
Ye ZHANG
;
Qingfeng LIU
;
Shiping ZHANG
;
Minjie WANG
;
Xiaotian XU
;
Jianping XIAO
;
Junlin YI
;
Jingwei LUO
;
Guozhen XU
;
Li GAO
Author Information
1. 100021,北京协和医学院 国家癌症中心/中国医学科学院肿瘤医院放疗科
- Keywords:
Nasopharyngeal neoplasms;
EBV-DNA level;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2018;27(6):543-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective It has been confirmed that Epstein-Barr virus ( EBV) is associated with the occurrence and development of the nasopharyngeal carcinoma ( NPC ) . We investigated the clinical significance of plasma concentrations of EBV-DNA in patients with NPC. Methods Since October,2013 to December,2016,471 patients were analyzed. The significantly associated between EBV-DNA before treatment and staging, tumor burden was analyzed. The survival rate of EBV-DNA before and after treatment was calculated. Results The median copies of pretreatment plasma EBV-DNA in patients is 137 copies,( range 0-494000) ,which is correlated with T stage,N stage,M stage,clinical stage and tumor burden load and that is statistically significant. Overall survival ( OS,P=0. 007) ,progression-free survival ( PFS,P=0. 011) and distant metastasis-free survival ( DMFS,P=0. 003) were significantly lower among patients with pretreatment plasma EBV-DNA more than 1300 copies/ml. Patients with detectable plasma EBV-DNA had significantly worse OS (P=0. 016),PFS (P=0. 000) and DMFS (P=0. 000) than patients with undetectable EBV-DNA after treatment. Cox multivariate analyze suggests that T stage and EBV-DNA after treatment were independent prognostic factors for OS,however the plasma EBV-DNA after treatment ( P=0. 006,0. 001) and N stage ( P=0. 037,0. 017) were independent prognostic factors for PFS and DMFS. Conclusions The plasma EBV-DNA level was significantly correlated with staging and tumor load before treatment in patients with NPC,and the prognosis of patients with higher copies before treatment could be worse. The plasma EBV-DNA after treatment is predictive for OS,PFS and DMFS.
