Research progresses in the mechanism and treatment of the impaired wound healing of combined radiation?trauma injury

VernacularTitle:放创复合伤创面难愈机制及治疗的研究进展
Author: Yonghong RAN ¹ ; Jining GAO ; Binghui LU ; Yingjuan HE ; Yongping SU ; Yuhui HAO
Author Information

1. 陆军军医大学军事预防医学院复合伤研究所创伤烧伤复合伤国家重点实验室重庆纳米医药工程技术中心
Keywords: Combined radiation trauma; Impaired wound healing; Mechanism; Therapy
From: Chinese Journal of Radiological Medicine and Protection 2018;38(11):874-880
CountryChina
Language:Chinese
Abstract: Combined radiation-trauma injury is mainly observed in radiation treatment of cancer and radiation injury with traumatic patients. The prominent problem of combined radiation-trauma injury is delayed or prolonged wound healing. The mechanism of the impaired wound healing is complicated, and the current effective treatment method are limited. This paper reviews the mechanism and treatment of this impaired wound healing, including the cellular depletion, stromal cell dysfunction, aberrant collagen deposition, microvascular damage, as well as the targeted therapies for the impaired wound healing such as stem cell repletion, antioxidant therapy, transforming growth factor beta-1 ( TGF-β1 ) modulation, and implantable biomaterials. This paper is designed to provide a reference for further deep research on the mechanism and treatment of radiation-trauma injury.