The impact of heartbeat on the left ventricular myocardial and the left anterior descending coronary arterial dosimetry following intensity modulated radiotherapy for left-sided breast cancer
10.3760/cma.j.issn.0254-5098.2018.10.005
- VernacularTitle:左侧乳腺癌调强放疗中心跳对左心室肌及左前降支剂量评估的影响
- Author:
Qian LI
1
;
Yong YIN
;
Ying TONG
;
Hong WEI
;
Pinjing CHENG
;
Guanzhong GONG
Author Information
1. 南华大学核科学技术学院
- Keywords:
Breast carcinoma;
Intensity modulated radiotherapy;
Left ventricular myocardial;
Left anterior descending;
Dose evaluation
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(10):747-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the impact of heartbeat on the left ventricular myocardial (mLV) and the left anterior descending (LAD) coronary arterial dosimetry following intensity modulated radiotherapy (IMRT) for left-sided breast carcinoma.Methods A total of 15 female patients who received electrocardiography gated 4D-CT scan in inspiratory breathing-holding were enrolled.According to cardiac cycle,20 time-phase images were reconstructed from 0 to 95％ at 5％ interval.Then,the mLV and the LAD were delineated respectively and the IMRT plans of the left breast carcinoma were generated based on 0％ phase CT images.The volume and dice similarity coefficient (DSC) of the mLV were calculated,and the variation range of the mLV and the LAD dose-volume indexes were compared among different phases.Results The average rate of DSC variation of mLV was eightfold of volume,which reached to 472.07％,and the average change rate of mLV (Dmean) was up to 41.95％.The difference of the mLV's volume and DSC was statistically significant between the maximum and minimum(t =-6.585,-28.870,P＜0.05),as well as the D V10,V20,V30 and V40(t=-5.260,-4.084,-3.592,-3.273,-2.566,P ＜0.05).The average change rate of the LAD's D was up to 130.14％.The difference of D V10,V20,V30 and V40 of LAD was statistically significant between the maximum and minimum(t =-9.758,-8.810,-8.682,-7.853,-6.205,P ＜ 0.05).Conclusions The dosimetry impact of heartbeat on mLV and LAD should not be ignored.
