Research progresses of the roles of disulfiram in anticancer activity and radiobiology
10.3760/cma.j.issn.0254-5098.2018.08.014
- VernacularTitle:双硫仑抗肿瘤活性及在放射生物学中的研究进展
- Author:
Hui LUO
1
;
Lili QIAO
;
Yonghan LI
;
Dandan ZHANG
;
Xuechao JIA
;
Wenna NIE
;
Xiaoli ZHENG
;
Yanan SUN
;
Chengcheng FAN
;
Hong GE
Author Information
1. 450014,郑州大学第二临床学院研究生部
- Keywords:
Disulfiram;
Cancer;
Clinical studies;
Molecular mechanism;
Radiosensitivity
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(8):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Disulfiram (DSF) has been widely used in clinical treatment of alcoholism.To date,in vivo and in vitro experiments have demonstrated that DSF has strong anti-cancer activity and could improve patient's survival,and the underlying mechanism has been elaborated.In addition,it was reported that,during radiotherapy,DSF could protect normal tissue and cells meanwhile enhance the radiosensitivity of tumor cells by forming complexes with copper ions,suppressing cancer stem cells and inhibiting ubiquitin-proteasome system activity in cancer cells.This review summarizes the completed and ongoing clinical trials of disulfiram,and its anti-tumor mechanisms and advances in radiation biology.
