Mid-term efficacy and prognosis of TPF regimen induction chemotherapy combined with IMRT for locally advanced nasopharyngeal carcinoma
10.3760/cma.j.issn.0254-5098.2018.08.007
- VernacularTitle:TPF方案诱导化疗不同给药方式联合调强放疗治疗局部晚期鼻咽癌的中期疗效及预后分析
- Author:
Xiuling LUO
1
;
Feng JIN
;
Ting BI
;
Weili WU
;
Yuanyuan LI
;
Jinhua LONG
;
Guoyan CHEN
;
Zhixu HE
;
Jianjiang ZHOU
;
Fang YU
Author Information
1. 贵州医科大学附属医院头颈肿瘤科
- Keywords:
Nasopharyngeal carcinoma;
Time-adjusted chemotherapy;
Intensity-modulated radiation therapy;
Mid-term outcomes;
Lymphocyte immune function
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(8):595-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy,adverse reactions and immune function of time-adjusted chemotherapy combined with intensity-modulated radiation therapy (IMRT) and conventional chemotherapy combined with IMRT for locally advanced nasopharyngeal carcinoma.Methods Random number grouping method was used to divide 66 cases of locally advanced nasopharyngeal carcinoma into 2 groups,of which 36 cases in the time-adjusted chemotherapy group and 30 cases in the conventional group.Both of them received docetaxel + cisplatin + fluorouracil regimen to induce chemotherapy for 2 cycles.The time-adjusted chemotherapy group was treated with intravenous injection of electronic automatic injection pump,the conventional group was treated with conventional intravenous infusion,and both groups were treated with synchronous cisplatin combined with IMRT.Calculated survival rate was generated by Kaplan-Meier method and long-term adverse reactions was evaluated according to CTC 3.0 criteria.Results The 3-year overall survival (OS) rate was 86.1％ and 93.3％ in the time-adjusted chemotherapy group and the regular group,the 3-year progress-free survival (PFS) was 83.3％ and 93.3％,the 3-year RFS was 88.5％ and 93.3％,and the 3-year recurrence-free survival was 94.1％ and 100％ respectively with no statistically significant difference (P ＞ 0.05).The dryness and hearing loss of the time-adjusted chemotherapy group had a decreasing trend compared with the conventional group.However,CD3 +,CD3 + CD4 +,CD3 + CD4 + CD8 +,and CD4 +/CD8 + of the time-adjusted chemotherapy group had an increasing trend compared with the conventional group.Conclusions Both time-adjusted chemotherapy and conventional chemotherapy combined with IMRT had comparable mid-term efficacy,but the former had lower adverse reactions,improved quality of life and immune function.Trial registration Chinese clinical trial registry,ChiCTR1800016809
