The optimal gamma passing rate thresholds of IMRT dosimetric verification in the treatment of esophageal cancer
10.3760/cma.j.issn.0254-5098.2018.04.010
- VernacularTitle:食管癌调强计划三维剂量验证中γ通过率最佳阈值的研究
- Author:
Lidong LIU
1
;
Zhen YANG
;
Xiaoping QIU
;
Yuqian ZHAO
;
Mingjun LEI
;
Ying CAO
;
Xiaoyu YANG
;
Du TANG
;
Hanyu WANG
;
Yuhao ZUO
Author Information
1. 南华大学核科学技术学院
- Keywords:
Intensity-modulated radiotherapy;
Receiver operating characteristic curve;
Optimal thresholds;
Dose volume histogram
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(4):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the optimal gamma passing rate of intensity-modulated radiotherapy (IMRT) dosimetric verification in the treatment of esophageal cancer using a three-dimensional dose verification system EDoseTM.Methods Twenty five esophageal cancer patients treated by 7-field IMRT were retrospectively reviewed.Measured dose distribution were reconstructed on CT image and evaluated by gamma analysis and DVH metrics using the EDoseTM system.Plans with DVH metrics dose difference ＜ 5％ or with gamma passing ＞ 90％ under 3％/3 mm criteria were accepted.The optimal gamma passing rate for criteria of 5％/3 mm,3％/3 mm,2％/2 mm were investigated by drawing the receiver operating characteristic (ROC) curves and calculating the Youden Index.The sensitivity and specificity of the these optimal thresholds in the plan verification were also analyzed.Results The optimal thresholds for global gamma indices with 5％/3 mm,3％/3 mm,2％/2 mm were 98.66％,94.84％,78.56％,respectively.In the 90％ common threshold,The sensitivity and specificity for common 90％ threshold and optimal threshold under 3％/3 mm criteria were 0.17 vs.0.85 and t 0.84 vs.0.27,respectively.The sensitivity and specificity were 0.89,0.65 and 0.23,0.47 for optimal thresholds under 5％/3 mm and 2％/2 mm criteria,respectively.Conclusions The sensitivity of optimal threshold gamma passing rate improved significantly compared with the common threshold (90％) at 3％/3 mm criteria.,The sensitivity and the specificity were more balanced at the 2％/2 mm criteria compared with those at 3％/3 mm criteria.
