Serum 8-hydroxy-2-deoxyguanosine level of radiation workers in hospitals
10.3760/cma.j.issn.0254-5098.2018.04.003
- VernacularTitle:放射工作人员血清中8-羟基脱氧鸟苷水平研究
- Author:
Yu GAO
1
;
Ping WANG
;
Chongbin TIAN
;
Lin HAN
;
Jie LI
;
Zhaonan WANG
;
Yanyan WU
;
Fengling ZHAO
;
Yumin LYU
Author Information
1. 450001,郑州大学公共卫生学院
- Keywords:
Ionizing radiation;
Radiation workers;
Interventional radiology;
8-hydroxy-2-deoxyguanosine
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(4):253-257
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of long-term low-dose ionizing radiation on 8-hydroxy-2-deoxyguanosine(8-OHdG) level in the serum of radiation workers in hospitals.Methods 307 age-and sex-matched hospital radiation workers were recruited by stratified random sampling method.After deleting the subjects without dosage information,230 individuals were divided into four groups according to their job title [including diagnostic radiology (n =75),radiotherapy (n =60),nuclear medicine (n =41) and interventional radiology (n =54)].Serum 8-OHdG level was measured by ELISA assay.Results According to the statistical analysis,there was significant difference in the serum 8-OHdG level among four groups (F =9.071,P ＜ 0.05),and the content of serum 8-OHdG was significantly higher in the interventional radiology group than that in the groups of diagnostic radiology,radiotherapy and nuclear medicine (t =-4.473,-3.011,-2.189,P ＜ 0.05).There were significant differences in serum 8-OHdG level among different dose groups and working period groups(F =7.659,3.058,P ＜ 0.05).The serum 8-OHdG levels significantly increased along with exposure dose and working period (r =0.300,0.142,P ＜ 0.05).Conclusions Serum 8-OHdG may be a potential biomarker of oxidative DNA damage in radiation workers exposed to low-dose ionizing radiation.
