Cardiac dosimetric evaluation of tangential VMAT technique in patients with left breast cancer after breast-conserving surgery, including internal mammary lymph node irradiation
10.3760/cma.j.issn.0254-5098.2018.03.004
- VernacularTitle:切向双弧容积弧形调强技术对保乳术后包括内乳淋巴结区照射的心脏剂量学评价
- Author:
Yan GAO
1
;
Heli ZHONG
;
Yayan ZHOU
;
Zhuangling LI
;
Weihao LI
;
Yajie LIU
Author Information
1. 暨南大学第二临床医学院深圳市人民医院肿瘤放疗科
- Keywords:
Breast cancer;
Cardiac toxicity;
Volumetric modulated arc therapy;
Intensity-modulated radiotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(3):180-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential heart sparing effects of tangential volumetric modulated arc therapy (T-VMAT) by comparing its dosimetric properties with conventional wedged tangential fields (W-TF) technique and 6-field intensity-modulated radiotherapy (6F-IMRT) in the locoregional radiotherapy of left breast cancer after conserving surgery,including internal mammary nodal irradiation.Methods Fifteen patients with left breast cancer were enrolled in this study.Three plans were generated for each patient:W-TF,6F-IMRT and T-VMAT with two arc segments of 50°.The prescription dose to planning tumor volume (PTV) was 50 Gy in 25 fractions.Dose-volume parameters and indices of conformity were calculated and compared for the PTV and organs at risk (OAR).Results Compared with W-TF,T-VMAT not only significantly decreased D D and the high dose areas (above 10 Gy) of the heart and left anterior descending branch (LAD) (P ＜ 0.05),but also had the trend of sparing the V5Gy although there was statistically significant difference (P ＞ 0.05).T-VMAT also significantly decreased Dmean V5Gy,V10Gy and V20Gy of the heart,as well as the D V5Gy and V10 Gy of LAD (P ＜ 0.05),compared to 6F-IMRT.Furthermore,T-VMAT did not result in higher V20Gy of ipsilateral lung and higher V5Gy of contralateral breast compared with W-TF (P ＞ 0.05).T-VMAT achieved distinctly better target coverage and conformity,meanwhile obviously lowered hot volume of V110 compared to W-TF (P ＜ 0.05).Conclusions T-VMAT not only significantly decreased the high dose areas,but also had the trend of sparing the low dose area for the heat and LAD.Moreover,there was no significant difference for V20Gy of ipsilateral lung and V5Gy of contralateral breast between T-VMAT and W-TF.
