Research progresses of green tea extract epigallocatechin-3-gallate on preventing and treating radiation injury

VernacularTitle:表没食子儿茶酸没食子酸酯用于放射损伤防治的研究进展
Author: Xuena NIU ^{1
,

2} ; Hanxi ZHAO ; Wanqi ZHU ; Ligang XING
Author Information

1. 250022 济南大学山东省医学科学院医学与生命科学学院
2. 山东大学附属山东省肿瘤医院放疗十科
Keywords: Radiation injury; Epigallocatechin-3-gallate; Protection
From: Chinese Journal of Radiological Medicine and Protection 2018;38(1):69-72
CountryChina
Language:Chinese
Abstract: Radiotherapy is one of the important cancer therapy methods that can lead to tissue damage including radiation lung injury,radiation esophageal injury,radiation skin damage and abnormal changes in hemopoietic system and immune system.Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea.It has been demonstrated that EGCG has biological effects of antiinflammatory,antioxidant,anti-apoptosis and regulating immunity.Recently some studies of cell and animal models suggest that EGCG has radioprotective effect,but few clinical research was reported.In this review,the studies about EGCG in preventing and treating radiation injury were summarized from antiradiation mechanism in order to enhance the understanding of the potential clinical application of EGCG.