Follow-up of radiosensitive tissues in children with congenital heart disease treated by interventional operation
10.3760/cma.j.issn.0254-5098.2018.01.008
- VernacularTitle:介入治疗术对先天性心脏病儿童辐射敏感组织影响的随访研究
- Author:
Ping WANG
1
;
Yinping SU
;
Yu GAO
;
Lin HAN
;
Jie LI
;
Yinghua FU
;
Fengling ZHAO
;
Yumin LYU
;
Quanfu SUN
Author Information
1. 河南省职业病防治研究院
- Keywords:
Interventional therapy;
Congenital heart disease;
Thyroid;
Peripheral blood;
Chromosomal aberrations;
Children
- From:
Chinese Journal of Radiological Medicine and Protection
2018;38(1):37-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand effects of the interventional operation on thyroid,peripheral blood indexes and chromosomal aberrations (CA) of peripheral lymphocyte of children with congenital heart disease (CHD).Methods Follow-up studies were conducted in 70 child patients undergoing cardiac catheterization and 23 with open heart surgery as control from 2010 to 2013.Postoperative follow-up examinations included thyroid ultrasound,blood routine indexes and analyses of CAs.Results Difference in thyroid ultrasound abnormality rate was not statistically significant between children with cardiac catheterization and control group (40.0％ vs.43.5％,P ＞ 0.05).There was no significant difference in white blood cell (WBC) count between interventional group and control group (P ＞ 0.05).The effects of disease type and operation time on thyroid ultrasound and WBC count were not observed (P ＞ 0.05).The frequency of chromosome aberrations,including acentric fragment,dicentrics and translocation in interventional group [(0.76 ± 0.07) ％],was higher than in control group [(0.25 ± 0.07) ％,(Z =-3.631,P ＜ 0.05],and the rates of acentric fragment and translocation were also higher in interventional group (Z =-2.531,-2.397,P ＜ 0.05).Conclusions Effect of intervention therapy on thyroid structure and WBC count in children with CHD was not observed,but the genotoxic effects remain in children with cardiac catheterization.
