Whole-tumor histogram analysis of apparent diffusion coefficient maps in grading diagnosis of ependymoma
10.3760/cma.j.issn.1005?1201.2018.10.006
- VernacularTitle:基于ADC图的全域直方图分析在室管膜瘤分级诊断中的价值
- Author:
Yong ZHANG
1
;
Jingliang CHENG
;
Ruiping ZHENG
;
Weijian WANG
;
Ke XU
;
Chendi ZHU
;
Qingqing LYU
Author Information
1. 450052,郑州大学第一附属医院磁共振科
- Keywords:
Magnetic resonance imaging;
Ependymoma;
Diagnosis;
differential
- From:
Chinese Journal of Radiology
2018;52(10):751-755
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of whole tumors volume based apparent diffusion coefficient histogram analysis in grading diagnosis of ependymoma. Methods Seventy?one patients with ependymal tumors were retrospectively analyzed, including 13 cases of WHOⅠ, 28 cases of WHOⅡ, 30 cases of WHO Ⅲ. Regions of interest (ROI) in the apparent diffusion coefficient maps of three groups on each layer of tumor level were drawn by using MaZda software and were analyzed using the whole tumors gray histogram. The histogram parameters of the three groups all fitted the normal distribution and homogeneity test of variance. The ANOVA analysis was used to compare the three groups. LSD-t test was used to compare the two groups to find out statistical significance of each parameter. Results Through histogram analysis of 9 parameters, three parameters were statistically significant (P<0.05), including variance, perc. 01％ and perc. 10％. The remaining 6 parameters had no significant difference between the three groups (P>0.05). Between the WHOⅠand the WHOⅡ, the sensitivity of perc.10％was 85.7％, the specificity was 87.7％, the area under the curve was 0.835, and the best cut-off value was 131.33. Between the WHOⅠand the WHOⅢ, the sensitivity of perc.10％was 85.7％, the specificity was 100.0％, the area under the curve was 0.872, and the cut-off was 126.5.Between the WHOⅡand the WHOⅢ, the sensitivity of variance was 68.4％, the specificity was 79.6％, the area under the curve was 0.794, and the cut-off was 2645.7. They had a high identification efficiency. Conclusion Whole-tumor histogram analysis of apparent diffusion coefficient maps could provide ancillary diagnostic value in grading diagnosis of ependymoma. Perc.10％and variance had a high diagnostic efficiency.
