Predictors of cerebral infarction in patients with ruptured anterior communicating artery aneurysms

Boli Lin; Lifang Chen; Junwei NI; Ting Yue; Weijian Chen; Bing Zhao; Yongchun Chen; Nengzhi Xia; Xianzhong Guo; Yunjun Yang

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Predictors of cerebral infarction in patients with ruptured anterior communicating artery aneurysms

VernacularTitle:前交通动脉瘤破裂后继发脑梗死的相关因素研究
Author: Boli LIN ¹ ; Lifang CHEN ; Junwei NI ; Ting YUE ; Weijian CHEN ; Bing ZHAO ; Yongchun CHEN ; Nengzhi XIA ; Xianzhong GUO ; Yunjun YANG
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1. 325000,温州医科大学附属第一医院放射科
Keywords: Aneurysm; Subarachnoid hemorrhage; Cerebral infarction; Tomography; X-ray computed
From: Chinese Journal of Radiology 2018;52(6):415-420
CountryChina
Language:Chinese
Abstract: Objective To investigate the incidence and predictors of cerebral infarction in patients with ruptured ACoA aneurysms, and to provide diagnostic and therapeutic information.Methods A total of 319 patients with ruptured ACoA aneurysms in our hospital from January 2009 to February 2015 were reviewed in this study. The author collected data regarding clinical characteristics, and measured the aneurysm morphologies on CTA images. Age, flow angle, vessel angle were analyzed by independent-samples t tests in patients with or without cerebral infarction. Mann-Whitney U tests were used for aneurysm size, aneurysm height, perpendicular height, neck size, size ratio, aspect ratio, aneurysm angle , World Federation of Neurosurgical Societies (WFNS) grade at admission and Fisher grade. Chi-square tests and Fisher's exact tests were used for sex, histories of hypertension, smoking and stroke, treatment modalities, anterior cerebral A1 segment configuration and angiographic vasospasm on CTA images. The multivariate logistic regression analyses were used to determine the independent risk factors of cerebral infarction using the stepwise regression method. Results Of the 319 patients, there were 253 without and 66 patients with cerebral infarction. Differences of age(53±11 vs 57±12,respectively;t=-2.415, P=0.016), Fisher grade [Ⅰ 23(9.1%), Ⅱ 27(10.7%), Ⅲ 74(29.2%), Ⅳ 129(51.0%) vs Ⅰ 1(1.5%), Ⅱ 7 (10.6% ), Ⅲ 13(19.7% ), Ⅳ 45(68.2% ), respectively;Z=-2.541, P=0.035] and treatment modalities [endovascular coil embolization 155(61.3% ), neurosurgical clipping 98(38.7% ) vs endovascular coil embolization 23(34.8%), neurosurgical clipping 43(65.2%), respectively;χ2=14.810, P<0.001] reached statistical significance. Multivariate analysis showed that Fisher grade Ⅳ(OR=10.36,95%CI 1.34-80.29, P=0.025) and neurosurgical clipping (OR=3.28, 95% CI 1.84-5.86,P<0.001)still had statistical significance. Conclusions Cerebral infarction in patients with ruptured ACoA aneurysms may be associated with Fisher grade and treatment modalities. Although there is difference between the two groups in age, it is not a predictor of the occurrence of cerebral infarction.