Clinical diagnostic value of presepsin in patients with rheumatoid arthritis complicated with bacterial infection
10.3760/cma.j.issn.1007-7480.2018.08.004
- VernacularTitle:血浆可溶性白细胞分化抗原14对类风湿关节炎患者合并细菌感染的临床诊断价值
- Author:
Yahui WEN
1
,
2
;
Yongfeng ZHANG
;
Yi ZHENG
Author Information
1. 100020 首都医科大学附属北京朝阳医院风湿免疫科
2. 北京市潞河医院通内科
- Keywords:
Arthritis,rheumatoid;
Soluble leukocyte differentiation antigen 14;
Bacterial infection
- From:
Chinese Journal of Rheumatology
2018;22(8):522-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical diagnostic value of plasma soluble leukocyte differentiation antigen 14 (presepsin) in patients with rheumatoid arthritis (RA) complicated with pulmonary bacterial infection.Methods A total of 133 patients with RA and 60 healthy controls were enrolled in this study.Fifty-eight RA patients were infected with lung bacterial infection and 75 patients were non-infected with RA.Among them,RA activity was performed in 43 patients and RA was stable in 32 patients.Chemilluminescence immunoassay was used to detect presepsin (P-SEP) in all subjects,and its correlation with inflammatory markers such as white blood cells,blood sedimentation rate and C-reactive protein was analyzed.Results The P-SEP of RA (561 ±142) pg/ml combined with pulmonary bacterial infection group was significantly higher than that of active RA group (378±100) pg/ml (t=8.12,P＜0.01),higher than that of stable RA group (197±68) pg/ml (t=8.51,P＜0.01) and healthy control group (113±9) pg/ml (t=13.75,P＜0.01).There was a positive correlation between P-SEP and leukocyte count in patients with RA complicated with pulmonary bacterial infection (r=0.627,P＜0.01).The degree of the disease activity was correlated with CRP (r=0.63,P＜O.O1),regardless of the P-SEP level (r=0.47,P=0.521).The optimal threshold value of P-SEP in diagnosing RA patients with bacterial infection was 458.9 pg/ml,with a sensitivity of 79.3％ and a specificity of 81.4％.Conclusion P-SEP has an important diagnostic value for the identification of bacterial infection in RA patients,which is not related to RA disease activity.
