Analysis of clinical factors on early pregnancy loss during in vitro fertilization-embryo transfer treatment and natural pregnancy
10.3760/cma.j.issn.0529-567x.2018.11.005
- VernacularTitle:体外受精-胚胎移植与自然妊娠后早期妊娠丢失的临床因素分析
- Author:
Mengjie FAN
1
;
Chan TIAN
;
Liang CHANG
;
Xiaoye WANG
;
Rong LI
Author Information
1. 100191,北京大学第三医院妇产科
- Keywords:
Abortion,spontaneous;
Pregnancy trimester,first;
Fertilization in vitro;
Embryo transfer;
Chromosome aberrations
- From:
Chinese Journal of Obstetrics and Gynecology
2018;53(11):755-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare differences of clinical factors related to early pregnancy loss between invitro fertilization-embryo transfer (IVF-ET) treatment and natural pegnancy. Methods A retrospective analysis was performed on the 363 cases of early pregnancy loss between Dec. 2015 to May 2016 in Peking University Third Hospital, during which 173 cases were after IVF-ET treatment(IVF-ET group), and others were natural pregnancies(natural group). Results The average age in IVF-ET group was significantly higher than that in the natural group [(34.1±4.3)versus(31.8±4.1)years old, P<0.01]. The terminating time of pregnancy loss in IVF-ET group was short than that in the natural group [(59.8±9.2) versus(69.9 ± 11.1)days, P<0.01]. The incidence of embryo abnormal chromosome in IVF-ET group was significantly lower than that in the natural group [57.2%(99/173)versus 74.2%(141/190), P<0.01], during which abnormal chromosome numbers were the most common. Conclusions The pregnancy loss of early pregnancy is mainly caused by chromosome abnormality. The proportion of chromosome abnormality in early pregnancy loss after IVF-ET is not higher than that of natural pregnancy, indicating that there are relatively reliable gametes and embryo safety in IVF treatment.
