Effect of gonadotropin-releasing hormone agonist used before surgery on natural pregnancy rates in patients with ovarian endometriomas
10.3760/cma.j.issn.0529-567x.2018.10.006
- VernacularTitle:手术前GnRH-a治疗对卵巢子宫内膜异位囊肿患者手术后自然妊娠的影响
- Author:
Xin CHEN
1
;
Haiyuan LIU
;
Jinghe LANG
;
Qingbo FAN
;
Honghui SHI
;
Dawei SUN
;
Jinhua LENG
;
Lan ZHU
;
Zhufeng LIU
Author Information
1. 100730,中国医学科学院北京协和医学院北京协和医院妇产科
- Keywords:
Endometriosis;
Gonadotropin-releasing hormone;
Laparoscopy;
Pregnancy
- From:
Chinese Journal of Obstetrics and Gynecology
2018;53(10):683-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of gonadotropin-releasing hormone agonist(GnRH-a) used before surgery on natural pregnancy rates in patients with ovarian endometriomas. Methods In this retrospective study, 57 patients with ovarian endometriomas who had a consecutive laparoscopic surgery between June, 2010 to September, 2015 in Peking Union Medical College Hospital were included. Those patients were divided into preoperative GnRH-a treatment group(n=31)and non-GnRH-a treatment group (n=26). There were no differences in patients'characteristics between the two groups. All of them had a desire for natural pregnancy postoperatively. GnRH-a was no longer used after surgery. After the surgical procedure, the patients were observed over a period of 12 months, during which the frequency of natural pregnancy was assessed. The two groups were compared in terms of natural pregnancy rates. Results Totally 33 patients had natural pregnancy after surgery. The univariate analysis showed that the pregnancy rates of age, r-AFS stage, infertility, preoperative use of GnRH-a, tumor size, tumor side, deep infiltrating endometriosis and adenomyosis did not have statistically significant differences (all P>0.05). The two classified logistic regression showed that OR for preoperative use of GnRH-a was 0.250(95％CI: 0.064-0.978)with a statistical difference(P=0.046). Conclusion The use of GnRH-a preoperatively may have a negative effect on natural pregnancy rates of patients after surgery with ovarian endometriomas.
