Clinical multicenter study of carboprost methylate suppository for cervical ripening prior to diagnostic hysteroscopy
10.3760/cma.j.issn.0529-567x.2018.09.004
- VernacularTitle:卡前列甲酯用于宫腔镜检查子宫颈预处理的多中心临床研究
- Author:
Hua DUAN
1
;
Min HAO
;
Sumin WANG
;
Yuejin MENG
;
Yan WANG
;
Rui YUAN
;
Xiang XUE
;
Qing YANG
;
Jun LIN
;
Yuanli HE
;
Yulin SHI
;
Jianhua LIU
;
Xin WANG
;
Sha WANG
Author Information
1. 100006,首都医科大学附属北京妇产医院妇科微创中心
- Keywords:
Hysteroscopy;
Carboprost;
Uterine cervical diseases;
Multicenter study
- From:
Chinese Journal of Obstetrics and Gynecology
2018;53(9):602-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness of carboprost methylate suppository for cervical ripening before diagnostic hysteroscopy in premenopausal women. Methods From July 2014 to July 2015, 1614 women who were undergone diagnostic hysteroscopy in 12 hospitals were randomly assigned into study group(n=1209)and control group(n=405). The cases in study group were given 1 mg carboprost methylate suppository in vagina before hysteroscopy, the cases in control group were given 1 mg placebo. The extent of cervical ripening, the time of dilated cervix, pain scoring, incidence of drug side reactions after 24, 48, 72 hours, satisfaction degree of operators and patients, the time of hysteroscopy, incidence of complications between the two groups were observed and compared. Results (1) Mean cervical widths in the study and control groups were 6.11 ± 1.11 and 5.95 ± 1.11, and showed a significant difference(P=0.034);the percentage of women requiring cervical dilatation in study group was lower than the percentage in control group significantly [28.3％(342/1209)versus 34.6％(140/405), P=0.020].(2) The time of dilated cervix in study group was shorter than the time in control group significantly [(34 ± 25) versus(52 ± 49)s, P=0.028] for the patients whose mean cervical widths≤4.(3)There was no significant difference in pain scores between the two groups(P>0.05).(4)The incidence of side reactions 24, 48, 72 hours after operation were no significant difference between the two groups (P>0.05). (5) The satisfaction degree of operators and patients, the time of hysteroscopy, incidence of complications between the two groups were no singnifcant difference between the two groups (all P>0.05). Conclusion Application of carboprost methylate suppository by vagina before hysteroscopy is an effective and safe method of cervical ripening.
