Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome
10.3760/cma.j.issn.0529-567x.2018.01.005
- VernacularTitle:高雄激素对多囊卵巢综合征患者辅助生殖治疗妊娠后产科并发症的影响
- Author:
Daimin WEI
1
;
Zhenzhen ZHANG
;
Ze WANG
;
Ping LI
;
Jianfeng WANG
;
Yanjun LIU
;
Jiangtao ZHANG
;
Yuhua SHI
Author Information
1. 山东大学附属生殖医院生殖内分泌科
- Keywords:
Polycystic ovary syndrome;
Hyperandrogenism;
Pregnancy complications;
Premature birth
- From:
Chinese Journal of Obstetrics and Gynecology
2018;53(1):18-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference in risks of obstetric complications of singleton pregnancy between women with hyperandrogenic polycystic ovary syndrome (PCOS) and women with normoandrogenic PCOS. Methods Prospective cohort study. This study was a secondary analysis of data collected during a multicenter randomized controlled clinical trial. Women who got clinical singleton pregnancy were grouped according to whether they were diagnosed with hyperandrogenism at baseline. There were 118 women with hyperandrogenism and 366 women without hyperandrogenism. The incidences of obstetric complications and birth weight were compared between the two groups. Results Women with hyperandrogenic PCOS had a significantly higher risk of preterm delivery than women with normoandrogenic PCOS [12.7％ (15/118) versus 3.6％ (13/366); OR=3.94, 95％CI: 1.82-8.56]. After adjustment of age, duration of infertility, body mass index, and fresh or frozen embryo transfer group, hyperandrogenism was still associated with an increased risk of preterm delivery (OR=3.67, 95％CI: 1.67-8.07). Compared with women with normoandrogenic PCOS, women with hyperandrogenic PCOS had similar risks of pregnancy loss, gestational diabetes mellitus, pre-eclampsia, placenta previa, and postpartum hemorrhage (all P>0.05). Birth weight as well as the risks of being small for gestational age and large for gestational age were also comparable between the two groups (all P>0.05). Conclusion In women with PCOS and singleton pregnancy, those with preconceptional hyperandrogenism have a higher risk of preterm delivery than those without hyperandrogenism.
