Blood Pressure and Heart Rate Variability in Alzheimer's Disease.
10.12779/dnd.2015.14.3.128
- Author:
Joong Seok KIM
1
;
Hyung Eun PARK
;
Yoon Sang OH
;
Jae Young AN
;
Sung Kyung PARK
;
Si Ryung HAN
;
Jeong Wook PARK
;
Dong Won YANG
;
Yong Soo SHIM
;
Kwang Soo LEE
Author Information
1. Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. neuronet@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
blood pressure;
heart rate;
sympathetic;
parasympathetic;
variation
- MeSH:
Alzheimer Disease*;
Blood Pressure*;
Case-Control Studies;
Electrocardiography, Ambulatory;
Heart Rate*;
Heart*;
Humans;
Memory;
Mild Cognitive Impairment
- From:Dementia and Neurocognitive Disorders
2015;14(3):128-134
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: Altered blood pressure (BP) and heart rate variations (HRVs) have been reported in Alzheimer's disease (AD). However, it is unclear how these two manifestations are associated with AD. Therefore, the objective of this study was to investigate BP and heart rate variability in AD compared to that in normal controls, patients with subjective memory impairment (SMI), and patients with mild cognitive impairment (MCI). METHODS: Case-control comparisons were made among AD (n=37), MCI (n=24), SMI (n=17), and controls (n=25). All patients underwent clinical and neuropsychological assessments with 24-h ambulatory BP and Holter monitoring. RESULTS: Patients with AD had higher pulse pressures than those in other groups. In addition, AD patients experienced blunted nocturnal BP dipping associated with declining cognitive status. AD patients also had larger ranges of HRV in parasympathetic domains compared to other groups, especially at night. CONCLUSIONS: Our results suggest that diurnal sympathetic and parasympathetic cardiac variability were significantly disturbed in mild cholinesterase-naive AD patients. This may be an indirect sign of disturbed integrity to the sleep-wake cycle in mild AD.
