Assessment of the hardness of salivary gland lesions in patients with Sj?gren′s syndrome by real-time shear wave elastography
10.3760/cma.j.issn.1004-4477.2018.03.009
- VernacularTitle:实时剪切波弹性成像评价干燥综合征患者涎腺弹性模量的初步临床研究
- Author:
Juan CHEN
1
;
Mingxing XIE
;
Jing WANG
;
Jun YOU
;
Song LENG
;
Yue SONG
;
Feixiang XIANG
;
Cheng YU
Author Information
1. 华中科技大学同济医学院附属协和医院超声影像科
- Keywords:
Shear wave elastography;
Sj?gren syndrome;
Elastic Modulus;
Parotid gland;
Submaxillary gland
- From:
Chinese Journal of Ultrasonography
2018;27(3):220-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of the real-time shear wave elastography(RT-SWE) in the assessment of salivary gland lesions by measuring the hardness of parotid gland and submaxillary gland in patients with Sj?gren′s syndrome (SS). Methods Forty patients with SS were chosen as SS group,and 35 age and gender matched healthy volunteers were chosen as control group.The patients were divided into mild SS group ( n =18) and severe SS group ( n =22) according to the decrease of uptake and secretion of salivary gland in Salivary gland scintigraphy.The Supersonic AixPlorer real-time quantitative diagnostic shear wave elastography was used to detect the parotid gland and submaxillary gland in 35 healthy volunteers and 40 patients.The RT-SWE elasticity indices of mean(Emean) was obtained and draw the SWE technology in the diagnosis of mild and severe SS patients with parotid and submandibular glands of the ROC curves. Results ① There was no significant difference in the Emean of left and right glands among the three groups (all P > 0.05). The Emean of parotid gland and submaxillary gland in patients with SS was higher than that in control group,especially in the severe SS group(all P <0.05). ②The cutoff value,sensitivity,specificity and the area under ROC for Emean with SWE diagnosing the parotid gland lesions of mild SS were 7.75 kPa,94.4%,97.1% and 0.998,and those in severe SS were 10.65 kPa, 90.9%,97.1% and 0.999,respectively.The cutoff value,sensitivity,specificity and the area under ROC for Emean with SWE diagnosing the the submaxillary glands lesions of mild SS were 8.15 kPa,100%,91.4%and 0.998,and those in severe SS were 10.40 kPa,95.5%,88.6% and 0.994,respectively.Conclusions RT-SWE can be successfully applied to assess parotid gland and submaxillary gland′s hardness in patients with SS,and provide a new method for the clinical evaluation of salivary gland diffuse lesions.
