Effects of adenosine stress on myocardial strain in healthy mice
10.3760/cma.j.issn.1004-4477.2018.01.019
- VernacularTitle:腺苷负荷对正常小鼠心肌应变的影响
- Author:
Lingying HUANG
1
;
Youbin DENG
;
Yani LIU
;
Yibin WANG
;
Jun ZHANG
;
Jie TIAN
;
Jiayu WANG
;
Yuhang MAO
Author Information
1. 华中科技大学同济医学院附属同济医院超声影像科
- Keywords:
Echocardiography;
stress;
Adenosine;
Mice;
Ventricular function;
left;
Speckle tracking imaging
- From:
Chinese Journal of Ultrasonography
2018;27(1):77-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of adenosine stress on myocardial strain in healthy mice by speckle tracking imaging (STI).Methods A high-resolution rodent ultrasound machine Vevo 2100 was used to perform conventional transthoracic echocardiography at baseline and after intravenous infusion of adenosine in 34 C57BL/6 mice.Echocardiography images from standardized parasternal long axis and short axis at papillary muscle level were consecutively acquired in real-time.All dynamic images were recorded for off-line analysis.Left ventricular myocardial mechanical strain parameters were acquired both under resting status and during adenosine stress.Results Thirty-four experimental animals successfully underwent STI before and during adenosine stress. There was no significant difference in heart rate,left ventricular structure and functional parameters between before and after the adenosine stress ( P >0.05).Global peak longitudinal strain value in left ventricular long-axis view was significantly increased during stress compared with those at resting status ( P < 0.05);while there was no significant increase in the global peak circumferential strain and global peak radial strain values in short-axis view at papillary muscle ( P >0.05).Conclusions Myocardial strain is obtained in healthy mice before and after adenosine stress.This provides an evidence to the application of stress echocardiography in mice with coronary heart disease or other cardiovascular disease in the future.
