Efficacy and safety of higenamine hydrochloride stress echocardiography for diagnosis of coronary artery disease
10.3760/cma.j.issn.1004-4477.2018.01.003
- VernacularTitle:盐酸去甲乌药碱负荷超声心动图诊断冠心病的有效性和安全性
- Author:
Hua BAI
1
;
Ligang FANG
;
Ruiyi XU
;
Yongtai LIU
;
Yihua HE
;
Shaomei HAN
;
Bilu LI
Author Information
1. 100730,中国医学科学院北京协和医院心内科
- Keywords:
Echocardiography;
stress;
Coronary artery disease;
Higenamine hydrochloride;
Adenosine
- From:
Chinese Journal of Ultrasonography
2018;27(1):11-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of higenamine hydrochloride(HG) stress echocardiography for diagnosis of coronary artery disease (CAD). Methods The study was designed as prospective,randomized,open-labled,positively controlled and crossover phase II multi-center clinical research.Ninety subjects who were suspected to have CAD were enrolled.HG dosage was titrated at 0.5,1, 2,4 μg.kg -1.min-1every 3 min.Adenosine was injected 140 μg.kg -1.min-1for 6 min with total dosage 0.8 mg/kg.Visual assessment of the left ventricle wall motionand 17-segment model were used for analysis of stress echocardiography.CAD was defined as identifying >50% diameter stenosis in at least one major coronary artery by coronary angiogram.All adverse reaction were recorded. Results For HG group,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value were 28.9%,89.7%, 57.1%,76.5% and 47.8%,respectively;for adenosine group,they were 26.7%,94.9%,58.3%,85.7%and 47.1%,respectively. There was no significant difference between the two groups( P > 0.05). The diagnostic sensitivities of HG and adenosine echocardiography for single vessel stenosis were 11.1% and 5.6%,respectively( P >0.05).Both HG and adenosine echocardiography have the same sensitivity with 37.5% for double vessel stenosis and 44.4% for triple vessel stenosis.Advers reaction rate was 84.4% in HG group and 92.2% in adenosine group( P >0.05).Conclusions HG stress echocardiography for CAD diagnosis has high specificity,good safety and low sensitivity,which are similar to adenosine echo.
