Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis.
10.3346/jkms.2014.29.7.950
- Author:
Yun Ha CHOI
1
;
Young Joon HONG
;
Youngkeun AHN
;
In Hyae PARK
;
Myung Ho JEONG
Author Information
1. The Division of Cardiology, Chonnam National University Hospital, Gwangju, Korea. hyj200@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Coronary Disease;
Neutrophils;
Lymphocytes;
Plaque;
Ultrasonography;
Interventional
- MeSH:
Aged;
C-Reactive Protein/analysis;
Coronary Angiography;
Coronary Artery Disease/*diagnosis/pathology;
Female;
Hospitals, University;
Humans;
Lymphocytes/*cytology;
Male;
Middle Aged;
Neutrophils/*cytology;
Odds Ratio;
Patients;
Plaque, Atherosclerotic/metabolism/*pathology;
Retrospective Studies;
Ultrasonography, Interventional
- From:Journal of Korean Medical Science
2014;29(7):950-956
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR< or =2.73 [n=370]) vs. high NLR group (NLR>2.73 [n=101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9+/-149.7 microL vs. 192.5+/-127.7 microL, P=0.001, and 32.7+/-26.8 microL vs. 22.8+/-19.4 microL, P=0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P=0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P=0.050) and NLR>2.73 (OR, 1.848; 95% CI, 1.016-3.360, P=0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P=0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR.
