Clinical Significance of Non-Alcoholic Fatty Liver Disease as a Risk Factor for Prehypertension.
10.3346/jkms.2014.29.7.973
- Author:
Jae Hong RYOO
1
;
Woo Taek HAM
;
Joong Myung CHOI
;
Min A KANG
;
So Hee AN
;
Jong Keun LEE
;
Ho Cheol SHIN
;
Sung Keun PARK
Author Information
1. Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. kkkmin7@hotmail.com
- Publication Type:Original Article
- Keywords:
Non-Alcoholic Fatty Liver Disease;
Blood Pressure;
Prehypertension
- MeSH:
Adult;
Blood Glucose;
Blood Pressure;
Cohort Studies;
Diabetes Mellitus, Type 2/complications/diagnosis;
Humans;
Incidence;
Male;
Middle Aged;
Non-alcoholic Fatty Liver Disease/complications/*diagnosis;
Prehypertension/diagnosis/*epidemiology/etiology;
Proportional Hazards Models;
Prospective Studies;
Risk Factors;
Smoking
- From:Journal of Korean Medical Science
2014;29(7):973-979
- CountryRepublic of Korea
- Language:English
-
Abstract:
Previous epidemiologic studies have shown the clinical association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limited information about the effect of NAFLD on the development of hypertension. Accordingly, we investigated the clinical association between NAFLD and prehypertension. A prospective cohort study was conducted on the 11,350 Korean men without prehypertension for 5 yr. The incidences of prehypertension were evaluated, and Cox proportional hazard model was used to measure the hazard ratios (HRs) for the development of prehypertension according to the degree of NAFLD (normal, mild, moderate to severe). The incidence of prehypertension increased according to NAFLD states (normal: 55.5%, mild: 63.7%, moderate to severe: 70.3%, P<0.001). Even after adjusting for multiple covariates, the HRs (95% confidence interval) for prehypertension were higher in the mild group (1.18; 1.07-1.31) and moderate to severe group (1.62; 1.21-2.17), compared to normal group, respectively (P for trend <0.001). The development of prehypertension is more potentially associated with the more progressive NAFLD than normal and milder state. These findings suggest the clinical significance of NAFLD as one of risk factors for prehypertension.
