Effect of intravenous tranexamic acid on perioperative hidden blood loss in percutaneous pedicle screw fixation for thoracolumbar fractures
10.3760/cma.j.issn.1671-7600.2018.04.004
- VernacularTitle:术前静脉应用氨甲环酸对经皮椎弓根螺钉固定胸腰椎骨折手术隐性失血量影响的前瞻性研究
- Author:
Yongyuan ZHANG
1
;
Xiji WANG
;
Qinpeng ZHAO
;
Chenyang SHUI
;
Honghui SUN
;
Dingjun HAO
Author Information
1. 710054,西安交通大学附属红会医院脊柱外科
- Keywords:
Tranexamic acid;
Thoracic vertebrae;
Lumbar vertebrae;
Minimally invasive surgical procedures;
Hidden blood loss
- From:
Chinese Journal of Orthopaedic Trauma
2018;20(4):291-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intravenous tranexamic acid (TXA) on perioperative hidden blood loss in percutaneous pedicle screw fixation for thoracolumbar fractures.Methods A prospective study was conducted in the 113 patients who would be subjected to percutaneous pedicle screw fixation for thoracolumbar fracture from January 2017 to December 2017.They were randomly assigned into an observation group (n =58) receiving intravenous drip of 15 mg/kg TXA 30 minutes preoperation or a control group (n =55) receiving intravenous drip of normal saline solution 30 minutes preoperation.The total blood loss and hidden blood loss 24 hours postoperation,D-dimer volume,incidences of deep vein thrombosis and other complications were recorded and compared between the 2 groups.Results There were 54 patients in the observation group and 50 patients in the control group for statistic analysis.The observation group had significantly less total blood loss (319.0 ± 140.5 mL) and hidden blood loss (242.0 ± 143.4 mL) 24 hours postoperation than the control group (418.7 ± 188.1 mL and 354.7 ± 181.9 mL,respectively) (P ＜ 0.05).There were no significant differences between the 2 groups in operation time or intraoperative blood loss (P ＞ 0.05).The volume of postoperative D-dimer was significantly higher than the preoperative value in both groups (P ＜ 0.05).No thromboembolic events occurred in either group.Conclusion Intravenous TXA may significantly reduce intraoperative hidden blood loss with no increased rik of thromboembolic events in percutaneous pedicle screw fixation for thoracolumbar fractures.
