Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients.
10.3346/jkms.2014.29.7.1025
- Author:
Mi Ae KIM
1
;
Moon Gyung YOON
;
Hyun Jung JIN
;
Yoo Seob SHIN
;
Hae Sim PARK
Author Information
1. Department of Allergy and Clinical Immunology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
- Publication Type:Brief Communication ; Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Pollinosis;
Immunotherapy;
Specific IgE;
Climate Change
- MeSH:
Adult;
Climate Change;
*Desensitization, Immunologic;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Immunoglobulin E/*blood;
Male;
Middle Aged;
Pollen/immunology;
Rhinitis, Allergic, Seasonal/*therapy;
Skin Tests;
Young Adult
- From:Journal of Korean Medical Science
2014;29(7):1025-1029
- CountryRepublic of Korea
- Language:English
-
Abstract:
Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenicity that influences clinical SIT outcomes. In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of SIT in patients undergoing SIT for tree and weed pollens.
