Meta analysis of efficacy and safety of non-steroidal anti-inflammatory drugs in preventing heterotopic ossification after hip arthroscopy
10.3760/cma.j.issn.1001-8050.2018.08.009
- VernacularTitle:非甾体类抗炎药物预防髋关节镜术后异位骨化有效性和安全性的Meta分析
- Author:
Haifeng HUANG
1
,
2
;
Xianteng YANG
;
Li SUN
;
Ruyin HU
;
Quan XIE
;
Zhen TIAN
;
Shanshan LI
;
Xiaobin TIAN
;
Jialiang TIAN
Author Information
1. 550002贵阳,贵州省人民医院骨科
2. 贵州大学医学院
- Keywords:
Arthroscopy;
Hip;
Ossification,heterotopic;
Anti-inflammatory agents,non-steroidal;
Meta analysis
- From:
Chinese Journal of Trauma
2018;34(8):721-727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) in preventing heterotopic ossification after hip arthroscopy.Methods Literature search was conducted in PubMed,Embase,Cochrane Library,CNKI and Wanfang data with time range from January 1973 to November 2017.Clinical case control articles on NSAIDs in preventing heterotopic ossification after hip arthroscopy were screened based on the inclusion and exclusion criteria.Meta analysis was done using RevMan 5.3 software to investigate the incidence of complications such as heterotopic ossification and gastrointestinal bleeding after hip arthroscopy in patients taking NSAIDs orally.Results Six articles were included in the study,with a total of 754 cases and 536 controls.NSAIDs reduced the incidence of heterotopic ossification after hip arthroscopy (RR =0.09,95％ CI 0.03-0.27,P ＜ 0.05).Selective COX-2 inhibitor celecoxib (RR =0.17,95％ CI 0.03-0.91,P ＜ 0.05) and PG synthase inhibitor of naproxen (RR =0.17,95％ CI 0.09-0.32,P ＜ 0.05) were also effective in preventing heterotopic ossification.There was no significant difference in the incidence of gastrointestinal complications between the cases and controls after NSAIDs prophylaxis (RR =2.17,95％ CI 0.92-5.12,P ＞ 0.05).Conclusion NSAIDs can effectively reduce the incidence of heterotopic ossification after hip arthroscopy and does not increase the incidence of postoperative gastrointestinal complications.Therefore,it is effective and safe to use NSAIDs to prevent the occurrence of heterotopic ossification after hip arthroscopy.
