Effect of circadian intracranial pressure changes on prognosis of patients with traumatic brain injury
10.3760/cma.j.issn.1001-8050.2018.03.002
- VernacularTitle:创伤性脑损伤颅内压波动对患者预后的影响
- Author:
Yicheng ZHOU
1
;
Xuepei LI
;
Qiuming ZHANG
;
Junwen GUAN
;
Hongli YAN
;
Hang YU
;
Yonghong LI
Author Information
1. 四川大学华西医院神经外科
- Keywords:
Brain injuries;
Intracranial pressure;
Prognosis;
Biorhythm
- From:
Chinese Journal of Trauma
2018;34(3):196-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of intracranial pressure fluctuation on the prognosis of patients with traumatic brain injury (TBI).Methods A retrospective case series study was conducted on the clinical data of 30 patients with TBI hospitalized between June 2012 and June 2014.There were 21 males and 9 females,aged (43.0 ± 19.8) years.After the intracranial pressure probe was implanted,the intracranial pressure of TBI patients was monitored continuously and the data were recorded per minute.A single cosine method was used in analyzing the circadian rhythm of intracranial pressure data.Furthermore,the ratio of the amplitude of the circadian parameter (A) to the median (M) value (A/M) was selected to evaluate the biologic rhythm of patients.The correlations of circadian rhythm parameter A/M with Glasgow Outcome Scale (GCS) and with extended Glasgow Outcome Scale (GOS-E) were analyzed using linear regression.Results The circadian rhythm was observed in all patients regardless of injury severity (P ＜ 0.01).The circadian rhythm parameter A/M of intracranial pressure was positively correlated with the GCS of patients at discharge (R2 =0.346,F =14.797,P ＜0.01) and with the GOS-E (R2 =0.356,F =15.502,P ＜ 0.01).Conclusion The intracranial pressure fluctuation of TBI patients follows circadian rhythm,which might be correlated with the prognosis of TBI patients.
