The association between serum γ-glutamyl transferase and the dynamics of prealbumin/model for end stage live disease in patients with liver failure caused by hepatitis B virus
10.3760/cma.j.issn.1000-6680.2017.12.003
- VernacularTitle:乙型肝炎相关性肝功能衰竭患者血清γ-谷氨酰胺转移酶与前白蛋白的动态变化及终末期肝病评分模型评分的相关性
- Author:
Li CHEN
1
;
Xiaoping HUANG
;
Yan WANG
;
Ying XU
;
Wei SUN
;
Haichao ZHU
;
Jianhe GAN
Author Information
1. 215006,苏州大学附属第一医院感染病科
- Keywords:
Liver failure;
Prealbumin;
γ-glutamyl transferase
- From:
Chinese Journal of Infectious Diseases
2017;35(12):715-718
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum γ-glutamyl transferase(γ-GT)level and its clinical significances in hepatitis B virus(HBV)-liver failure(LF)patients.Methods γ-GT levels were detected in 89 LF patients,30 cases with cirrhosis and 30 healthy controls.Difference of serum γ-GT between survival group and death group in LF patients and dynamics of γ-GT after hospitalization were studied. Survival rate between γ-GT increase group and decrease group were compared.The associations of γ-GT with model for end stage live disease(MELD)and prealbumin were calculated.Results At baseline,the γ-GT levels in LF,cirrhosis and healthy control groups were(149.61 ± 69.86),(123.96 ± 59.52)and (48.28 ± 10.25)U/L,respectively,the difference among groups was significant(F= 178.150,P<0.05).The survival group in LF patients showed significant increase of γ-GT one week after hospitalization compared with death group([75.27 ± 10.34]vs[29.47 ± 5.05],t=5.40,P<0.05). The γ-GT increase group showed higher survival rate than γ-GT decrease group[76.19%(48/63)vs 23.08%[6/26],χ2=21.76,P<0.05].Serum γ-GT level in LF patients was positively correlated with both MELD score and prealbumin(r=0.709 and -0.627,respectively,both P<0.05).Conclusions The rise of γ-GT may indicate a better prognosis in LF patients.Serum γ-GT positively correlates with prealbumin and both could reflect the regeneration of hepatocytes.
