Hepatitis B surface antigen levels in hepatitis B virus-related hepatocellular carcinoma: a retrospective cross-sectional study
10.3760/cma.j.issn.1000-6680.2017.10.005
- VernacularTitle:乙型肝炎病毒相关肝细胞癌中血清乙型肝炎表面抗原表达的横断面研究
- Author:
Qian HUANG
1
;
Dawu ZENG
;
Jing DONG
;
Yueyong ZHU
;
Jiaji JIANG
;
Yurui LIU
Author Information
1. 350001,福州福建医科大学附属协和医院感染科
- Keywords:
Hepatitis B surface antigens;
Carcinoma,hepatocellular;
Liver cirrhosis;
Barcelona clinical liver cancer
- From:
Chinese Journal of Infectious Diseases
2017;35(10):595-599
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of serum hepatitis B surface antigen (HBsAg) levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).Methods A total of 226 cases of HBV-related HCC were collected from June 2009 to December 2013.Demographic characteristics of patients with different barcelona clinica liver cancer (BCLC) stages,the status of cirrhosis and HBsAg levels with different virological indicators were compared.HBsAg quantification was tested by chemiluminescence.The statistical analysis was conducted by t test,x2 test,Kruskal-Wallis H rank sum test and Mann-Whitney U rank sum test.Results A total of 226 cases were included with 201male patients and 25 female patients.HBsAg levels in HBV-related HCC patients with different ages were significantly different (x2=12.30,P =0.015),but with no statistical difference in those with different gender (Z=-0.35,P＞0.05).The HBsAg levels were not significantly different between patients with or without liver cirrhosis (Z =-0.80,P =0.419).HBsAg levels in liver cirrhosis cases with different liver function stages were not significant different (x2=2.15,P=0.341).HBsAg levels in HBeAg-positive group or HBV DNA positive group were significantly higher than those in HBeAg-negative group or HBV DNA negative group,respectively (Z =-3.67 and-4.80,respectively,both P＜0.01).The HBsAg levels in patients with different BCLC stages were not significantly different (x2 8.05,P =0.09).No significant differences were found in HBsAg levels between patients with or without portal vein violation,lymph node transfer or distant transfer (Z=-0.65,-0.03 and-1.24,respectively,all P＞ 0.05).The constituent ratios of patients with different HBsAg levels in different BCLC stages were statistically different (x2 =28.17,P-0.005).Conclusions There are no significant differences of HBsAg levels in patients with different BCLC stages,indicating that HBsAg may not be a contributor for disease progression after emergence of HCC.
