Effects of Xiaoyao Kang'ai Jieyu Formula on Depressive Symptoms of Mice with Breast Cancer Related Depression
10.3969/j.issn.1005-5304.2018.11.011
- VernacularTitle:逍遥抗癌解郁方对乳腺癌并发抑郁症模型小鼠抑郁样指征的影响
- Author:
Pan MENG
1
;
Hui-Zhen HUANG
;
Qin YANG
;
Hong-Qing ZHAO
;
Hui YANG
;
Yuan-Shan HAN
;
Jia LING
;
Yu-Hong WANG
Author Information
1. 湖南中医药大学中药粉体与创新药物省部共建国家重点实验室培育基地
- Keywords:
Xiaoyao Kang'ai Jieyu Formula;
breast cancer related depression;
monoamine neurotransmitters;
HPA axis;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(11):46-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Xiaoyao Kang'ai Jieyu Formula on mice with breast cancer related depression; To explore its mechanism. Methods BALB/c female mice were set as study objects. Subaxillary injection of inflammatory 4T1 cells and intraperitoneal injection of corticosterone were used to establish a model of breast cancer related depression. According to the consumption of sugar water, mice were randomly divided into blank group, model group, paclitaxel group, Xiaoyao Kang'ai Jieyu Formula group, chemotherapy+fluoxetine group, and chemotherapy + Xiaoyao Kang'ai Jieyu Formula group. After 21 days, sucrose preference test, open-field test, and novelty feeding test were performed to detect changes in the behavior of mice in each group. ELISA were used to detected the contents of corticotrophin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT) in plasma, and the contents of 5-hydroxytryptamine (5-HT), dopamine (DA), norepinephrine (NE), tumor markers carbohydrate antigen CA153, CA125 and carcinoembryonic antigen (CEA) in serum. Results Compared with the blank group, the consumption of sugar, horizontal and vertical movements of mice in the model group significantly decreased (P<0.01, P<0.05); the latency of ingestion significantly increased (P<0.01, P<0.05); the levels of tumor markers CA153, CA125, CEA and some indexes of HPA axis significantly increased (P<0.01); the expressions of monoamine neurotransmitter NE, DA and 5-HT significantly decreased (P<0.01). Compared with the model group, sugar consumption and autonomic activity significantly increased in the chemotherapy + Xiaoyao Kang'ai Jieyu Formula group, and behavioral despair condition was improved (P<0.01, P<0.05); the content of tumor markers and some indexes related to HPA axis significantly decreased (P<0.01, P<0.05); the contents of 5-HT, DA and NE significantly increased (P<0.01, P<0.05). Conclusion The combination of Xiaoyao Kang'ai Jieyu Formula and paclitaxel can effectively relieve the depressive symptoms of breast cancer related depression.
